Project Title: ClearDrum®: an acoustically-optimised silk fibroin membrane for the treatment of chronic middle ear disease.
ClearDrum® is an implantable synthetic ear drum that simplifies and quickens surgery to repair a hole in the eardrum.
Chronic middle ear disease (CMED), afflicts almost 5% of the world’s population and is particularly prevalent in Australian indigenous populations, with an incidence rate of 90% in indigenous children. The World Health Organization estimates that 65-330 million individuals have CMED, and 60% of them have a significant hearing impairment, directly linked to poor education, lower employment opportunities and a decline in mental health. The current treatments leave many of these individuals with ongoing problems, often requiring multiple surgeries.
The breakthrough project ClearDrum®, developed by Ear Science Institute Australia (ESIA) will offer a real solution for ear drum repair and other middle ear disease solutions.
Cleardrum® aims to provide an ‘off-the-shelf’ solution, to treat chronic middle ear disease, leading to perforation in a single, straightforward surgical procedure. Developed in conjunction with Deakin University, ClearDrum® is truly revolutionary due to its 3D shape and its mechanical and acoustic properties.
ESIA partnered up with Deakin University’s Future Fibers Hub to develop a device prototype based on silk fibroin biomaterial and shaped as a human tympanic membrane. We now have a working prototype and a contracted manufacturer, with a strong international intellectual property position.
The project was awarded $3.89m grant from The Wellcome Trust for its clinical studies and the first clinic trial is scheduled for mid-2021.
This ground-breaking device speeds up the healing of a damaged eardrum and will contribute to treating one of the biggest causes of hearing loss in indigenous populations in Western Australia and also across the world.
BMTH Round: Three
State: Western Australia
Project Partner: Deakin University
- MTPConnect Grant: $993,500
- Industry Contribution: $348,915
Duration: October 2020 - November 2022