Hit ID Platform

At the core of a successful drug discovery is a high-quality chemical library. A fit-for-purpose drug discovery library is not a random collection of compounds, but a collection of carefully curated chemistry that is designed to cover the diversity of drug-like chemistry space, and provide tractable starting points for medicinal chemistry optimisation.

This project will build on a national framework to provide Australian drug discovery organisations access to a comprehensive Hit ID platform that includes:

• a fit for purpose drug discovery library (up to 300,000 compounds);
• an ultra-high throughput screening facility;
• fragment-based drug design capability;
• a state of the art software platform for in silico drug discovery.

Outcomes: Working copies of the ALIDC library (315,000 compounds) have been stored at Compounds Australia and used for more than 15 projects by teams at the member institutes. A complete reformat of the library is underway to generate focused library sub-sets and facilitate accessibility by the wider research community.

Visit Cancer Therapeutics CRC for more details  |  Twitter: cancercrc & GRIDD_GU  |  LinkedIn: Cancer Therapeutics CRC