Hit ID Platform
At the core of a successful drug discovery is a high-quality chemical library. A fit-for-purpose drug discovery library is not a random collection of compounds, but a collection of carefully curated chemistry that is designed to cover the diversity of drug-like chemistry space, and provide tractable starting points for medicinal chemistry optimisation.
This project will build on a national framework to provide Australian drug discovery organisations access to a comprehensive Hit ID platform that includes:
- a fit for purpose drug discovery library (up to 300,000 compounds);
- an ultra-high throughput screening facility;
- fragment-based drug design capability;
- a state of the art software platform for in silico drug discovery.
Outcomes: Working copies of the ALIDC library (315,000 compounds) have been stored at Compounds Australia and used for more than 15 projects by teams at the member institutes. A complete reformat of the library is underway to generate focused library sub-sets and facilitate accessibility by the wider research community.
|Consortium lead|| |
Cancer Therapeutics CRC Pty Ltd (CTx)
|Consortium members|| |
UniQuest, Walter and Eliza Hall Institute (WEHI), Children's Cancer Institute (CCI), Griffith University / Compounds Australia
|Project duration||August 2017 - June 2019 (Finished)|
|Contact||Brendon Monahan, Cancer CRC - firstname.lastname@example.org|
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